diff --git a/src/common/engine/i_interface.cpp b/src/common/engine/i_interface.cpp
index 338f36c6c..a78b5b30f 100644
--- a/src/common/engine/i_interface.cpp
+++ b/src/common/engine/i_interface.cpp
@@ -6,6 +6,7 @@
 #include "gstrings.h"
 #include "version.h"
 #include "m_argv.h"
+#include "m_random.h"
 
 static_assert(sizeof(void*) == 8,
 	"Only LP64/LLP64 builds are officially supported. "
@@ -182,3 +183,12 @@ int FStartupSelectionInfo::SaveInfo()
 	return DefaultIWAD;
 }
 
+FString GameUUID;
+static FRandom pr_uuid("GameUUID");
+
+FString GenerateUUID()
+{
+	FString uuid;
+	uuid.AppendFormat("%08X-%04X-4%03X-9%03X-%08X%04X", pr_uuid.GenRand32(), pr_uuid(UINT16_MAX), pr_uuid(4095), pr_uuid(4095), pr_uuid.GenRand32(), pr_uuid(UINT16_MAX));
+	return uuid;
+}
diff --git a/src/common/engine/i_interface.h b/src/common/engine/i_interface.h
index e901705f2..ecff3f6b1 100644
--- a/src/common/engine/i_interface.h
+++ b/src/common/engine/i_interface.h
@@ -13,6 +13,9 @@ class FConfigFile;
 class FArgs;
 struct FTranslationID;
 
+extern FString GameUUID;
+FString GenerateUUID();
+
 struct SystemCallbacks
 {
 	bool (*G_Responder)(event_t* ev);	// this MUST be set, otherwise nothing will work
diff --git a/src/common/menu/savegamemanager.cpp b/src/common/menu/savegamemanager.cpp
index 961a01ea6..ac041d622 100644
--- a/src/common/menu/savegamemanager.cpp
+++ b/src/common/menu/savegamemanager.cpp
@@ -48,6 +48,7 @@
 #include "savegamemanager.h"
 #include "m_argv.h"
 #include "i_specialpaths.h"
+#include "i_interface.h"
 
 CVAR(String, save_dir, "", CVAR_ARCHIVE | CVAR_GLOBALCONFIG | CVAR_SYSTEM_ONLY);
 FString SavegameFolder;
@@ -191,6 +192,7 @@ void FSavegameManagerBase::NotifyNewSave(const FString &file, const FString &tit
 		{
 			node->SaveTitle = title;
 			node->CreationTime = myasctime();
+			node->UUID = GameUUID;
 			node->bOldVersion = false;
 			node->bMissingWads = false;
 
@@ -210,6 +212,7 @@ void FSavegameManagerBase::NotifyNewSave(const FString &file, const FString &tit
 	auto node = new FSaveGameNode;
 	node->SaveTitle = title;
 	node->CreationTime = myasctime();
+	node->UUID = GameUUID;
 	node->Filename = file;
 	node->bOldVersion = false;
 	node->bMissingWads = false;
@@ -560,6 +563,27 @@ bool FSavegameManagerBase::RemoveNewSaveNode()
 	return false;
 }
 
+int FSavegameManagerBase::RemoveUUIDSaveSlots()
+{
+	if (GameUUID.IsEmpty())
+		return -1;
+
+	// Make sure there's any saves in the list first.
+	if (!SaveGames.Size())
+		ReadSaveStrings();
+
+	int index = -1;
+	for (int i = SaveGames.Size() - 1; i >= 0; --i)
+	{
+		auto& save = SaveGames[i];
+		if (save == &NewSaveNode || save->UUID.Compare(GameUUID))
+			continue;
+
+		index = RemoveSaveSlot(i);
+	}
+	return index;
+}
+
 DEFINE_ACTION_FUNCTION(FSavegameManager, RemoveNewSaveNode)
 {
 	PARAM_SELF_STRUCT_PROLOGUE(FSavegameManagerBase);
@@ -581,9 +605,15 @@ DEFINE_ACTION_FUNCTION(FSavegameManager, ExtractSaveData)
 	ACTION_RETURN_INT(self->ExtractSaveData(sel));
 }
 
+DEFINE_ACTION_FUNCTION(FSavegameManager, RemoveUUIDSaveSlots)
+{
+	PARAM_SELF_STRUCT_PROLOGUE(FSavegameManagerBase);
+	ACTION_RETURN_INT(self->RemoveUUIDSaveSlots());
+}
 
 DEFINE_FIELD(FSaveGameNode, SaveTitle);
 DEFINE_FIELD(FSaveGameNode, Filename);
+DEFINE_FIELD(FSaveGameNode, UUID);
 DEFINE_FIELD(FSaveGameNode, bOldVersion);
 DEFINE_FIELD(FSaveGameNode, bMissingWads);
 DEFINE_FIELD(FSaveGameNode, bNoDelete);
diff --git a/src/common/menu/savegamemanager.h b/src/common/menu/savegamemanager.h
index 4dd2eb69d..a5d84d212 100644
--- a/src/common/menu/savegamemanager.h
+++ b/src/common/menu/savegamemanager.h
@@ -12,6 +12,7 @@ struct FSaveGameNode
 	FString SaveTitle;
 	FString Filename;
 	FString CreationTime;
+	FString UUID;
 	bool bOldVersion = false;
 	bool bMissingWads = false;
 	bool bNoDelete = false;
@@ -57,6 +58,7 @@ public:
 	FSaveGameNode *GetSavegame(int i);
 	void InsertNewSaveNode();
 	bool RemoveNewSaveNode();
+	int RemoveUUIDSaveSlots();
 
 };
 
diff --git a/src/g_game.cpp b/src/g_game.cpp
index 9c38bd5aa..1bad3c24c 100644
--- a/src/g_game.cpp
+++ b/src/g_game.cpp
@@ -2009,6 +2009,7 @@ void G_DoLoadGame ()
 	arc("Save Version", SaveVersion);
 	arc("Engine", engine);
 	arc("Current Map", map);
+	arc("GameUUID", GameUUID);
 
 	if (engine.CompareNoCase(GAMESIG) != 0)
 	{
@@ -2386,6 +2387,7 @@ void G_DoSaveGame (bool okForQuicksave, bool forceQuicksave, FString filename, c
 	savegameinfo.AddString("Software", buf)
 		.AddString("Engine", GAMESIG)
 		("Save Version", ver)
+		("GameUUID", GameUUID)
 		.AddString("Title", description)
 		.AddString("Current Map", primaryLevel->MapName.GetChars());
 
diff --git a/src/g_level.cpp b/src/g_level.cpp
index 825979d4d..11d06c844 100644
--- a/src/g_level.cpp
+++ b/src/g_level.cpp
@@ -636,6 +636,7 @@ void G_InitNew (const char *mapname, bool bTitleLevel)
 			players[i].playerstate = PST_ENTER;	// [BC]
 
 		STAT_StartNewGame(mapname);
+		GameUUID = GenerateUUID();
 	}
 
 	usergame = !bTitleLevel;		// will be set false if a demo
diff --git a/src/menu/loadsavemenu.cpp b/src/menu/loadsavemenu.cpp
index f701083fc..429d1c60b 100644
--- a/src/menu/loadsavemenu.cpp
+++ b/src/menu/loadsavemenu.cpp
@@ -102,6 +102,7 @@ void FSavegameManager::ReadSaveStrings()
 						FString iwad = arc.GetString("Game WAD");
 						FString title = arc.GetString("Title");
 						FString creationtime = arc.GetString("Creation Time");
+						FString uuid = arc.GetString("GameUUID");
 
 
 						if (engine.Compare(GAMESIG) != 0 || savever > SAVEVER)
@@ -128,6 +129,7 @@ void FSavegameManager::ReadSaveStrings()
 
 						FSaveGameNode *node = new FSaveGameNode;
 						node->Filename = entry.FilePath.c_str();
+						node->UUID = uuid;
 						node->bOldVersion = oldVer;
 						node->bMissingWads = missing;
 						node->SaveTitle = title;
diff --git a/wadsrc/static/zscript/engine/ui/menu/loadsavemenu.zs b/wadsrc/static/zscript/engine/ui/menu/loadsavemenu.zs
index 82b5ea4bf..589951b2e 100644
--- a/wadsrc/static/zscript/engine/ui/menu/loadsavemenu.zs
+++ b/wadsrc/static/zscript/engine/ui/menu/loadsavemenu.zs
@@ -38,6 +38,7 @@ struct SaveGameNode native
 {
 	native String SaveTitle;
 	native readonly String Filename;
+	native readonly String UUID;
 	native bool bOldVersion;
 	native bool bMissingWads;
 	native bool bNoDelete;
@@ -68,6 +69,7 @@ struct SavegameManager native ui
 	native SaveGameNode GetSavegame(int i);
 	native void InsertNewSaveNode();
 	native bool RemoveNewSaveNode();
+	native int RemoveUUIDSaveSlots();
 
 }